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Pawan Sinha also shares how proper sleep will help to lead a better life. Get the latest top stories, current affairs, sports, business, entertainment, politics, astrology, spirituality, and many more here only on ABP News. The vision of the channel is 'Aapko Rakhe Aagey' -the promise of keeping each individual ahead and informed. ABP News is best defined as a responsible channel with a fair and balanced approach that combines prompt reporting with insightful analysis of news and current affairs. ABP News maintains the repute of being a people's channel.

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ABP News. Horoscope today, July 25, , Thursday. For Love. Gut instinct: a diagnostic tool? It is generally accepted that with experience clinicians develop the ability to identify patients who present with malignancy prior to a formal diagnosis. This ability cannot be quantified, nor is it a plausible substitute for investigation.

This study aimed to evaluate the association between instinct and head and neck cancer diagnosis. A prospective study of patients requiring urgent diagnostic procedures for suspected cancer between August and December was performed. Risk factors, symptoms, signs and the clinician's impression were recorded. These were graded and subsequently correlated with histology findings. Twenty-seven patients, with a mean age of Thirty per cent of patients were referred under the two-week pathway and A diagnosis of cancer was made in 37 per cent of patients.

This study highlights the importance of clinical suspicion in cancer diagnosis. Although clinical suspicion cannot be quantified, it should be regarded as an integral part of patient assessment. Diagnostic Tools of Pleural Effusion. Pleural effusion is not a rare disease in Korea. The diagnosis of pleural effusion is very difficult, even though the patients often complain of typical symptoms indicating of pleural diseases.

Pleural effusion is characterized by the pleural cavity filled with transudative or exudative pleural fluids, and it is developed by various etiologies. The presence of pleural effusion can be confirmed by radiological studies including simple chest radiography, ultrasonography, or computed tomography. Identifying the causes of pleural effusions by pleural fluid analysis is essential for proper treatments. This review article provides information on the diagnostic approaches of pleural effusions and further suggested ways to confirm their various etiologies, by using the most recent journals for references.

A computer-aided ECG diagnostic tool. Jordan lacks companies that provide local medical facilities with products that are of help in daily performed medical procedures. Because of this, the country imports most of these expensive products. Consequently, a local interest in producing such products has emerged and resulted in serious research efforts in this area. The main goal of this paper is to provide local the north of Jordan clinics with a computer-aided electrocardiogram ECG diagnostic tool in an attempt to reduce time and work demands for busy physicians especially in areas where only one general medicine doctor is employed and a bulk of cases are to be diagnosed.

The tool was designed to help in detecting heart defects such as arrhythmias and heart blocks using ECG signal analysis depending on the time-domain representation, the frequency-domain spectrum, and the relationship between them. The application studied here represents a state of the art ECG diagnostic tool that was designed, implemented, and tested in Jordan to serve wide spectrum of population who are from poor families.

Costs, ease of interface, and accuracy indicated the usefulness of the tool and its use as an assisting diagnostic tool. This EAACI Task Force document aims at providing the readers with a comprehensive and complete overview of the currently available tools for diagnosis of nasal and sino-nasal disease. We have tried to logically order the different important issues related to history taking, clinical examination and additional investigative tools for evaluation of the severity of sinonasal disease into a consensus document.

A panel of European experts in the field of Rhinology has contributed to this consensus document on Diagnostic Tools in Rhinology. Ultrasound as Diagnostic Tool for Diaphragmatic Myoclonus. Background Diaphragmatic myoclonus is a rare disorder of repetitive diaphragmatic contractions, acknowledged to be a spectrum that includes psychogenic features.

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Electromyography has been the diagnostic tool most commonly used in the literature. Methods To test if we could perform a noninvasive technique to delineate the diaphragm as the source of abnormal movements and demonstrate distractibility and entrainability, we used B-mode ultrasound in a patient with diaphragmatic myoclonus. Results Ultrasound imaging clearly delineated the diaphragm as the source of her abdominal movements.

We were able to demonstrate entrainability of the diaphragm to hand tapping to a prescribed rhythm set by examiner. Conclusion We recommend the use of ultrasound as a noninvasive, convenient diagnostic tool for further studies of diaphragmatic myoclonus. We agree with previous findings that diaphragmatic myoclonus may be a functional movement disorder, as evidenced by distractibility and entrainability demonstrated on real-time video with ultrasonography.

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Power Plant Model Validation Tool. The PPMV is used to validate generator model using disturbance recordings. The PPMV tool contains a collection of power plant models and model validation studies, as well as disturbance recordings from a number of historic grid events. Canine parvovirus CPV infection is one of the most important and common infectious diseases in dogs, in particular affecting young puppies when maternal antibodies have waned and vaccine-induced antibodies have not yet developed.

The mortality rate remains high. Therefore, a rapid and safe diagnostic tool is essential to diagnose the disease to 1 provide intensive care treatment and 2 to identify virus-shedding animals and thus prevent virus spread. Whilst the detection of antibodies against CPV is considered unsuitable to diagnose the disease, there are several different methods to directly detect complete virus, virus antigen or DNA.

Additionally, to test in commercial laboratories, rapid in-house tests based on ELISA are available worldwide. However, results on sensitivity vary and high numbers of false-negative results are commonly reported, which potentially leads to misdiagnosis. Polymerase chain reaction PCR is a very sensitive and specific diagnostic tool.

It also provides the opportunity to differentiate vaccine strains from natural infection when sequencing is performed after PCR. Integrated Wind Power Planning Tool. The goal is to integrate a mesoscale numerical weather prediction NWP model with purely statistical tools in order to assess wind power fluctuations, with focus on long term power system planning for future wind farms as well as short term forecasting for existing wind farms.

Currently, wind power fluctuation models are either purely statistical or integrated with NWP models of limited resolution. This task constitutes a preparative study for later implementation of features accounting for NWP forecast errors in the DTU Wind Energy maintained Corwind code - a long term wind power planning tool. Within the framework of PSO research related to operational short term wind power prediction will be carried out, including a comparison of forecast quality at different mesoscale NWP model resolutions and development of a statistical wind power prediction tool taking input from WRF.

The integrated prediction model will allow for the description of the expected variability in wind power production in the coming hours to days, accounting for its spatio-temporal dependencies, and depending on the prevailing weather conditions defined by the WRF output. The output from the integrated short term prediction tool constitutes scenario forecasts for the coming period, which can then be fed into any type of system model or decision making problem to be solved. The high resolution of the WRF results loaded into the integrated prediction model will ensure a high accuracy. The project commenced October 1, , and the goal is to integrate a numerical weather prediction NWP model with purely statistical tools in order to assess wind power fluctuations, with focus on long term power system planning for future wind farms as well as short term forecasting for existing wind farms.

This integrated prediction model will allow for the description of the expected variability in wind power production in the coming hours to days, accounting for its spatio-temporal dependencies, and depending on the prevailing weather conditions defined by the WRF output. The output from the integrated prediction tool constitute scenario forecasts for the coming period, which can then be fed into any type of system model or decision making problem to be solved.

The high resolution of the WRF results loaded into the integrated prediction model will ensure a high accuracy data basis is available for use in the decision making process of the Danish. Photovoltaic array space power plus diagnostics experiment. The objective of the Photovoltaic Array Space Power Plus Diagnostics PASP Plus experiment is to measure the effects of the interaction of the low- to mid-altitude space environment on the performance of a diverse set of small solar-cell arrays planar and concentrator, representative of present and future military technologies under differing conditions of velocity-vector orientation and simulated by biasing high-voltage operation.

Solar arrays to be tested include Si and GaAs planar arrays and several types of GaAs concentrator arrays. Diagnostics a Langmuir probe and a pressure gauge and a transient pulse monitor to measure radiated and conducted EMI during arcing will be used to determine the impact of the environment on array operation to help verify various interactions models. Results from a successful PASP Plus flight will furnish answers to important interactions questions and provide inputs for design and test standards for photovoltaic space- power subsystems.

Diagnostic Tools for the Systemic Reform of Schools. This paper presents three interrelated diagnostic tools that can be used by school staff as they begin to plan a systemic reform effort. These tools are designed to help educators reflect on their experiences in creating changes in their school and to examine the current barriers to and supports for the change process.

The tools help school design…. The fault detecting program is now incorporated into a software suite that identifies potential faults early in the design phase of systems ranging from printers to vehicles and robots, saving time and money. Case studies are a useful vehicle for developing and testing conceptual models, classification systems, diagnostic tools and models, and stressor-response relationships. Furthermore, case studies focused on specific places or issues of interest to the Agency provide an excellent Test results for components and subsystems are given as well as final system tests.

Also included are appendices which describe the major subsystems and present supporting documentation such as block diagrams, schematics, circuit board artwork, drawings, test procedures and test reports. Hand and power tools : A compilation. Some hand and power tools were described. Section One describes several tools and shop techniques that may be useful in the home or commercial shop. Section Two contains descriptions of tools that are particularly applicable to industrial work, and in Section Three a number of metal working tools are presented.

Green Power Community Tools and Resources. GPCs are a subset of the Green Power Partnership; municipalities or tribal governments where government, businesses, and residents collectively use enough green power to meet GPP requirements. Nanotechnology: emerging tool for diagnostics and therapeutics. Nanotechnology is an emerging technology which is an amalgamation of different aspects of science and technology that includes disciplines such as electrical engineering, mechanical engineering, biology, physics, chemistry, and material science.

It has potential in the fields of information and communication technology, biotechnology, and medicinal technology. It involves manipulating the dimensions of nanoparticles at an atomic scale to make use of its physical and chemical properties. All these properties are responsible for the wide application of nanoparticles in the field of human health care. Promising new technologies based on nanotechnology are being utilized to improve diverse aspects of medical treatments like diagnostics , imaging, and gene and drug delivery. This review summarizes the most promising nanomaterials and their application in human health.

We consider in this work the probabilistic approach to model-based diagnosis when applied to electrical power systems EPSs. Our probabilistic approach is formally well-founded, as it based on Bayesian networks and arithmetic circuits.

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We investigate the diagnostic task known as fault isolation, and pay special attention to meeting two of the main challenges. To address the challenge of model development, we develop a systematic approach to representing electrical power systems as Bayesian networks, supported by an easy-to-use speci.

To address the real-time reasoning challenge, we compile Bayesian networks into arithmetic circuits. Arithmetic circuit evaluation supports real-time diagnosis by being predictable and fast. In essence, we introduce a high-level EPS speci. The time taken to compute the most probable explanation using arithmetic circuits has a small mean of 0. In experiments with data from ADAPT we also show that arithmetic circuit evaluation substantially outperforms joint tree propagation and variable elimination, two alternative algorithms for diagnosis using Bayesian network inference.

A cross-sectional analysis of the development of CP was performed in a prospectively collected multicenter cohort including patients after a first episode of acute pancreatitis. A total of patients with acute pancreatitis followed-up for a median period of 57 interquartile range, months were included.

Differences between the tools regarding the following criteria led to significant changes in the total number of diagnoses of CP: abdominal pain, recurrent pancreatitis, moderate to marked ductal lesions, endocrine and exocrine insufficiency, pancreatic calcifications, and pancreatic pseudocysts. Differences between diagnostic tools for CP are mainly attributed to presence of clinical symptoms, endocrine insufficiency, and certain morphological complications. Evaluating online diagnostic decision support tools for the clinical setting.

Clinical decision support tools available at the point of care are an effective adjunct to support clinicians to make clinical decisions and improve patient outcomes. We developed a methodology and applied it to evaluate commercially available online clinical diagnostic decision support DDS tools for use at the point of care. We identified 11 commercially available DDS tools and assessed these against an evaluation instrument that included 6 categories; general information, content, quality control, search, clinical results and other features.

We developed diagnostically challenging clinical case scenarios based on real patient experience that were commonly missed by junior medical staff. The evaluation was divided into 2 phases; an initial evaluation of all identified and accessible DDS tools conducted by the Clinical Information Access Portal CIAP team and a second phase that further assessed the top 3 tools identified in the initial evaluation phase. An evaluation panel consisting of senior and junior medical clinicians from NSW Health conducted the second phase. Of the eleven tools that were assessed against the evaluation instrument only 4 tools completely met the DDS definition that was adopted for this evaluation and were able to produce a differential diagnosis.

The second phase of the evaluation was focused on assessing diagnostic accuracy for the top 3 tools identified in the initial phase. Best Practice ranked highest overall against the 6 clinical case scenarios used. Overall the differentiating factor between the top 3 DDS tools was determined by diagnostic accuracy ranking, ease of use and the confidence and. Autonomous power expert fault diagnostic system for Space Station Freedom electrical power system testbed.

The objectives of the program are to establish artificial intelligence technology paths, to craft knowledge-based tools with advanced human-operator interfaces for power systems, and to interface and integrate knowledge-based systems with conventional controllers. The key tasks include establishing knowledge bases for system diagnostics , fault detection and isolation analysis, on-line information accessing through PMC, enhanced data management, and multiple-level, object-oriented operator displays.

The first prototype of the diagnostic expert system for fault detection and isolation has been developed. A corresponding troubleshooting technique is also described. Saliva as a diagnostic tool for oral and systemic diseases. Early disease detection is not only vital to reduce disease severity and prevent complications, but also critical to increase success rate of therapy. Saliva has been studied extensively as a potential diagnostic tool over the last decade due to its ease and non-invasive accessibility along with its abundance of biomarkers, such as genetic material and proteins.

This review will update the clinician on recent advances in salivary biomarkers to diagnose autoimmune diseases Sjogren's syndrome, cystic fibrosis , cardiovascular diseases, diabetes, HIV, oral cancer, caries and periodontal diseases. Considering their accuracy, efficacy, ease of use and cost effectiveness, salivary diagnostic tests will be available in dental offices. It is expected that the advent of sensitive and specific salivary diagnostic tools and the establishment of defined guidelines and results following rigorous testing will allow salivary diagnostics to be used as chair-side tests for several oral and systemic diseases in the near future.

Developing a tool to support diagnostic delivery of dementia. It is increasingly recognised that there are challenges affecting the current delivery of dementia diagnoses.

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Steps are required to address this. Current good practice guidelines provide insufficient direction and interventions from other healthcare settings do not appear to fully translate to dementia care settings. This project has taken a sequential two-phase design to developing a tool specific to dementia diagnostic delivery.

Interviews with 14 participants explored good diagnostic delivery. Thematic analysis produced key themes overcoming barriers, navigation of multiple journeys and completing overt and covert tasks that were used to inform the design of a tool for use by clinicians, patients and companions. The tool was evaluated for acceptability in focused group discussions with 13 participants, which indicated a desire to use the tool and that it could encourage good practice. Adaptations were highlighted and incorporated to improve acceptability.

Future research is now required to further evaluate the tool. Optics assembly for high power laser tools. There is provided a high power laser rotational optical assembly for use with, or in high power laser tools for performing high power laser operations. In particular, the optical assembly finds applications in performing high power laser operations on, and in, remote and difficult to access locations. The optical assembly has rotational seals and bearing configurations to avoid contamination of the laser beam path and optics.

Three submersible diagnostic tools were developed to enable more precise and cost-effective means of sampling environmental waters and assessing remedial strategies. The In Situ Sampler IS2 and In Situ Sampler for Biphasic Water Monitoring IS2B , designed for sampling groundwater or simultaneous pore- and surface water, use affordable off-the-shelf solid phase extraction technology, applicable to a broad range of organic and inorganic contaminants.

The IS2 is ideal for dynamic groundwater systems where discrete sampling may fail to capture temporal variations, leading to inaccurate assessment of exposure and risk. A day sampling event in a Cr VI -impacted aquifer captured previously undetected tidally-induced fluctuations, while improving the reporting limit 8-fold. The IS2B elucidates contaminant partitioning and bioavailability, and was validated in a wetland-shallow aquifer system with the pesticide fipronil. For groundwater remedial testing, the In Situ Microcosm Array ISMA was developed to integrate laboratory column treatability studies with pilot-scale field-testing, thus minimizing costs associated with sequential lab and field analyses.

In situ operation maintains geo chemical and microbial groundwater parameters often destroyed by extraction and laboratory storage. Onboard effluent capture permits the deployment well to return to monitoring status immediately after instrument removal. All tools employ reusable internal components and may be operated by solar power. Case study results highlight the capabilities and application range of the each technology. Molecular diagnostics of inflammatory disease: New tools and perspectives. This essay reviews current approaches to establish novel molecular diagnostic tools for inflammatory skin diseases.

Moreover, it highlights the importance of stratifying patients according to molecular signatures and revising current outdated disease classification systems to eventually reach the goal of personalized medicine. Trace elements and some drugs can be identified in hair and it seems likely that other organic chemicals will be identifiable in the future.

Since hair is so easily collected, stored, and analyzed it promises to be an ideal complement to serum and urine analysis as a diagnostic tool. Polymerase chain reaction: A molecular diagnostic tool in periodontology. This review discusses the principles of polymerase chain reaction PCR and its application as a diagnostic tool in periodontology.

The searches were limited to articles in English language and the articles describing PCR process and its relation to periodontology were collected and used to prepare a concise review. PCR has now become a standard diagnostic and research tool in periodontology. Various studies reveal that its sensitivity and specificity allow it as a rapid, efficient method of detecting, identifying, and quantifying organism. Different immune and inflammatory markers can be identified at the mRNA expression level, and also the determination of genetic polymorphisms, thus providing the deeper insight into the mechanisms underlying the periodontal disease.

Diagnosis demystified: CT as diagnostic tool in endodontics. Diagnosis in endodontics is usually based on clinical and radiographical presentations, which are only empirical methods. The role of healing profession is to apply knowledge and skills towards maintaining and restoring the patient's health. Recent advances in imaging technologies have added to correct interpretation and diagnosis.

CT is proving to be an effective tool in solving endodontic mysteries through its three-dimensional visualisation. CT imaging offers many diagnostic advantages to produce reconstructed images in selected projection and low-contrast resolution far superior to that of all other X-ray imaging modalities.

This case report is an endeavour towards effective treatment planning of cases with root fracture, root resorption using spiral CT as an adjuvant diagnostic tool. A defect-driven diagnostic method for machine tool spindles. Simple vibration-based metrics are, in many cases, insufficient to diagnose machine tool spindle condition. These metrics couple defect-based motion with spindle dynamics; diagnostics should be defect-driven. A new method and spindle condition estimation device SCED were developed to acquire data and to separate system dynamics from defect geometry.

Based on this method, a spindle condition metric relying only on defect geometry is proposed. Application of the SCED on various milling and turning spindles shows that the new approach is robust for diagnosing the machine tool spindle condition. Oral exfoliative cytology as a rapid diagnostic tool for paracoccidioidomycosis. Paracoccidioidomycosis is a common deep mycosis in South America. It is caused by the dimorphic fungus Paracoccidioides brasiliensis.

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We report a case of a year-old Brazilian man with oral lesions due to paracoccidioidomycosis, which was diagnosed by exfoliative cytology without any special staining. We highlight this diagnostic tool as a simple, low-cost, painless, non-invasive and fast method for the diagnosis of paracoccidioidomycosis. Information on students' development of science skills is essential for teachers to evaluate and improve their own education, as well as to provide adequate support and feedback to the learning process of individual students.

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The present study explores and discusses the use of performance assessments as a diagnostic tool for formative assessment to inform teachers and guide instruction of science skills in primary education. Three performance assessments were administered to more than students in grades 5 and 6 of primary education. Students performed small experiments using real materials while following the different steps of the empirical cycle. The mutual relationship between the three performance assessments is examined to provide evidence for the value of performance assessments as useful tools for formative evaluation.

Differences in response patterns are discussed, and the diagnostic value of performance assessments is illustrated with examples of individual student performances. Findings show that the performance assessments were difficult for grades 5 and 6 students but that much individual variation exists regarding the different steps of the empirical cycle. Evaluation of scores as well as a more substantive analysis of students' responses provided insight into typical errors that students make. It is concluded that performance assessments can be used as a diagnostic tool for monitoring students' skill performance as well as to support teachers in evaluating and improving their science lessons.

New methodology to baseline and match AME polysilicon etcher using advanced diagnostic tools. As process controls tighten in the semiconductor industry, the need to understand the variables that determine system performance become more important. For plasma etch systems, process success depends on the control of key parameters such as: vacuum integrity, pressure, gas flows, and RF power.

It is imperative to baseline, monitor, and control these variables. This paper presents an overview of the methods and tools used by Motorola BMC fabrication facility to characterize an Applied Materials polysilicon etcher. Tool performance data obtained from our traditional measurement techniques are limited in their scope and do not provide a complete picture of the ultimate tool performance. Presently the BMC traditional characterization tools provide a snapshot of the static operation of the equipment under test EUT ; however, complete evaluation of the dynamic performance cannot be monitored without the aid of specialized diagnostic equipment.

The diagnostic methodology used to baseline and match key parameters of qualified production equipment has had an immense impact on other equipment characterization in the facility. It has resulted in reduced cycle time for new equipment introduction as well. Monitoring of ionospheric turbulence spatial features by SEE diagnostic tools. SEE, recall, appears as a result of conversion or scattering of HF pump-driven plasma waves off the geomagnetic field aligned electron density irregularities striations. It is found that a slow time scale of s dynamics of DSEE, namely, characteristics of its slow overshoot and undershoot effects are determined by the spectral shape and intensity of the striations at, respectively, the development and relaxation stages.

The development of Doppler global velocimetry is described from its inception to its use as a flow diagnostics tool. Its evolution is traced from an elementary one-component laboratory prototype, to a full three-component configuration operating in a wind tunnel at focal distances exceeding 15 m. As part of the developmental process, several wind tunnel flow field investigations were conducted. These included supersonic flow measurements about an oblique shock, subsonic and supersonic measurements of the vortex flow above a delta wing, and three-component measurements of a high-speed jet.

The Executive Summary includes an overview of the main points from each section. Supporting details, diagrams, figures, and other information are included in subsequent sections. A glossary, acronym list, appendices, and references are included at the end of this report. Net energy analysis: Powerful tool for selecting electric power options.

A number of net energy analysis studies have been conducted in recent years for electric power production from coal, oil and uranium fuels; synthetic fuels from coal and oil shale; and heat and electric power from solar energy. This technique is an excellent indicator of investment costs, environmental impact and potential economic competitiveness of alternative electric power systems for energy planners from the Eastern European countries considering future options.

Energy conservation is also important to energy planners and the net energy analysis technique is an excellent accounting system on the extent of energy resource conservation. The author proposes to discuss the technique and to present the results of his studies and others in the field. The information supplied to the attendees will serve as a powerful tool to the energy planners considering their electric power options in the future.

Automated health management is a critical functionality for complex aerospace systems. A wide variety of diagnostic algorithms have been developed to address this technical challenge. In this paper, we describe a formal framework developed for benchmarking of diagnostic technologies. The benchmarking approach provides a systematic, empirical basis to the testing of diagnostic software and is used to provide performance assessment for different diagnostic algorithms.

Structured illumination microscopy as a diagnostic tool for nephrotic disease. Nylk, Jonathan; Pullman, James M. Nephrotic disease is a group of debilitating and sometimes lethal diseases affecting kidney function, specifically the loss of ability to retain vital proteins in the blood while smaller molecules are removed through filtration into the urine. Treatment routes are often dictated by microscopic analysis of kidney biopsies.

Podocytes within the glomeruli of the kidney have many interdigitating projections foot processes , which form the main filtration system. Nephrotic disease is characterised by the loss of this tightly interdigitating substructure and its observation by electron microscopy EM is necessitated as these structures are typically nm wide, with 40nm spacing.

Diagnosis by EM is both expensive and time consuming; it can take up to one week to complete the preparation, imaging, and analysis of a single sample. We propose structured illumination microscopy SIM as an alternative, optical diagnostic tool. Our results show that SIM can resolve the structure of fluorescent probes tagged to podocin, a protein localised to the periphery of the podocyte foot processes. Three-dimensional podocin maps were acquired in healthy tissue and tissue from patients diagnosed with two different nephrotic disease states; minimal change disease and membranous nephropathy.

These structures correlated well with EM images of the same structure. Preparation, imaging, and analysis could be achieved in several hours. Additionally, the volumetric information of the SIM images revealed morphological changes in disease states not observed by EM. This evidence supports the use of SIM as a diagnostic tool for nephrotic disease and can potentially reduce the time and cost per diagnosis. Diagnostic tools for mixing models of stream water chemistry. Mixing models provide a useful null hypothesis against which to evaluate processes controlling stream water chemical data.

Diagnostic tools are developed to determine the approximate rank of the data set and to assess lack of fit of the data. This permits identification of processes that violate the assumptions of the mixing model and can suggest the dominant processes controlling stream water chemical variation. This technique is applied to a number of sites at the Panola Mountain Research Watershed located near Atlanta, Georgia. Prostate cancer diagnostics : Clinical challenges and the ongoing need for disruptive and effective diagnostic tools.

The increased incidence and the significant health burden associated with carcinoma of the prostate have led to substantial changes in its diagnosis over the past century. Despite technological advancements, the management of prostate cancer has become progressively more complex and controversial for both early and late-stage disease. The limitations and potential harms associated with the use of prostate-specific antigen PSA as a diagnostic marker have stimulated significant investigation of numerous novel biomarkers that demonstrate varying capacities to detect prostate cancer and can decrease unnecessary biopsies.

However, only a few of these markers have been approved for specific clinical settings while the others have not been adequately validated for use. This review systematically and critically assesses ongoing issues and emerging challenges in the current state of prostate cancer diagnostic tools and the need for disruptive next generation tools based on analysis of combinations of these biomarkers to enhance predictive accuracy which will benefit clinical diagnostics and patient welfare.

Published by Elsevier Inc. Analysis of quaternary ammonium compounds in estuarine sediments by LC-ToF-MS: very high positive mass defects of alkylamine ions provide powerful diagnostic tools for identification and structural elucidation. A sensitive and robust method of analysis for quaternary ammonium compounds QACs in marine sediments is presented. Recognized in this study are the exceptionally high positive mass defects characteristic of alkylammonium or protonated alkylamine ions.

No alternative and chemically-viable elemental formulas exist within Accurate mass measurements of diagnostic collision induced dissociation fragment ions and heavy isotope peaks were obtained and also seen to be uniquely heavy compared to other elemental formulae. In the case of BACs, the ability to resolve masses of alkylamine fragment ions is greater than it is for molecular ions, opening up a wide range of potential applications. The power of utilizing a combination of approaches is illustrated with the identification of non-targeted DADMAC C8:C8 and C8:C10, two widely used biocides previously unreported in environmental samples.

Improvements in diagnostic tools for early detection of psoriatic arthritis. Psoriatic arthritis PsA is a heterogeneous chronic inflammatory disease characterized by a wide clinical spectrum.

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The early diagnosis of PsA is currently a challenging topic. Areas covered: The literature was extensively reviewed for studies addressing the topic area "diagnosis of psoriatic arthritis". This review will summarize improvements in diagnostic tools , especially referral to the rheumatologist, the role of patient history and clinical examination, laboratory tests, and imaging techniques in getting an early and correct diagnosis of PsA. Expert commentary: Due to the heterogeneity of its expression, PsA may be easily either overdiagnosed or underdiagnosed. A diagnosis of PsA should be taken into account every time a patient with psoriasis or a family history of psoriasis shows peripheral arthritis, especially if oligoarticular or involving the distal interphalangeal joints, enthesitis or dactylitis.

Magnetic resonance imaging and ultrasonography are useful for diagnosing PsA early, particularly when isolated enthesitis or inflammatory spinal pain occur. Psychological autopsy PA studies constitute one main evidence base for this conclusion. However, there has been little reflection on the reliability and validity of this method. In this article, we scrutinize PA studies with particular focus on the diagnostic process and demonstrate that they cannot constitute a valid evidence base for a strong relationship between mental disorders and suicide.

We show that most questions asked to assign a diagnosis are impossible to answer reliably by proxies, and thus, one cannot validly make conclusions. Thus, as a diagnostic tool psychological autopsies should now be abandoned. Social network diagnostics : a tool for monitoring group interventions. Background Many behavioral interventions designed to improve health outcomes are delivered in group settings. To date, however, group interventions have not been evaluated to determine if the groups generate interaction among members and how changes in group interaction may affect program outcomes at the individual or group level.

Methods This article presents a model and practical tool for monitoring how social ties and social structure are changing within the group during program implementation. The approach is based on social network analysis and has two phases: collecting network measurements at strategic intervention points to determine if group dynamics are evolving in ways anticipated by the intervention, and providing the results back to the group leader to guide implementation next steps.

This process aims to initially increase network connectivity and ultimately accelerate the diffusion of desirable behaviors through the new network. This article presents the Social Network Diagnostic Tool and, as proof of concept, pilot data collected during the formative phase of a childhood obesity intervention. Results The number of reported advice partners and discussion partners increased during program implementation.

Density, the number of ties among people in the network expressed as a percentage of all possible ties, increased from 0. Conclusions The observed two-fold increase in network density represents a significant shift in advice partners over the intervention period. Using the Social Network Tool to empirically guide program activities of an obesity intervention was feasible. Diagnostic algorithms DAs are key to enabling automated health management. These algorithms are designed to detect and isolate anomalies of either a component or the whole system based on observations received from sensors.

In recent years a wide range of algorithms, both model-based and data-driven, have been developed to increase autonomy and improve system reliability and affordability. However, the lack of support to perform systematic benchmarking of these algorithms continues to create barriers for effective development and deployment of diagnostic technologies. In this paper, we present our efforts to benchmark a set of DAs on a common platform using a framework that was developed to evaluate and compare various performance metrics for diagnostic technologies.

The paper presents the fundamentals of the benchmarking framework, the ADAPT system, description of faults and data sets, the metrics used for evaluation, and an in-depth analysis of benchmarking results obtained from testing ten diagnostic algorithms on the ADAPT electrical power system testbed. Development and validation of a premature ejaculation diagnostic tool. Diagnosis of premature ejaculation PE for clinical trial purposes has typically relied on intravaginal ejaculation latency time IELT for entry, but this parameter does not capture the multidimensional nature of PE.

Therefore, the aim was to develop a brief, multidimensional, psychometrically validated instrument for diagnosing PE status. The questionnaire development involved three stages: 1 Five focus groups and six individual interviews were conducted to develop the content; 2 psychometric validation using three different groups of men; and 3 generation of a scoring system.

The development and validation of this new PE diagnostic tool has resulted in a new, user-friendly, and brief self-report questionnaire for use in clinical trials to diagnose PE. Comparative genomic hybridisation as a supportive tool in diagnostic pathology. Aims: Patients with multiple tumour localisations pose a particular problem to the pathologist when the traditional combination of clinical data, morphology, and immunohistochemistry does not provide conclusive evidence to differentiate between metastasis or second primary, or does not identify the primary location in cases of metastases and two primary tumours.

Because this is crucial to decide on further treatment, molecular techniques are increasingly being used as ancillary tools.

Methods: The value of comparative genomic hybridisation CGH to differentiate between metastasis and second primary, or to identify the primary location in cases of metastases and two primary tumours was studied in seven patients. CGH is a cytogenetic technique that allows the analysis of genome wide amplifications, gains, and losses deletions in a tumour within a single experiment. The patterns of these chromosomal aberrations at the different tumour localisations were compared. Results: In all seven cases, CGH patterns of gains and losses supported the differentiation between metastasis and second primary, or the identification of the primary location in cases of metastases and two primary tumours.

Conclusion: The results illustrate the diagnostic value of CGH in patients with multiple tumours. Medical thoracoscopy: a useful diagnostic tool for undiagnosed pleural effusion. We aimed to assess the role of medical thoracoscopy in patients with undiagnosed pleural effusion. Patiens presenting with pleural effusion underwent three pleural aspirations.

Patients in whom pleural fluid analysis was inconclusive underwent closed pleural biopsy for diagnostic confirmation. Patients in whom closed pleural biopsy was incolcusive underwent medical thoracoscopy using a rigid thoracoscope with a viewing angle of zero degrees was done under local anaesthesia and sedation with the patient lying in lateral decubitus position with the affected side up.



Biopsy specimens from parietal pleura were obtained under direct vision and were sent for histopathological examination. Of the patients with pleural effusion who were studied, pleural fluid examination established the diagnosis in 81 malignancy 33, tuberculosis 33, pyogenic 14 and fungal 1 ; 47 patients underwent closed pleural biopsy and a diagnosis was made in 28 patients malignancy 24, tuberculosis 4. Medical thoracoscopy is a useful tool for the diagnosis of pleural diseases. The procedure is safe with minimal complications. Laryngeal electromyography as a diagnostic tool for Parkinson's disease.

To study the laryngeal electromyography pattern in patients with Parkinson's disease PD and vocal complaints at different stages of the disease. Cross-sectional cohort study. Ninety-four adults with PD and vocal complaints at different stages of the disease according to the Hoehn and Yahr scale underwent laryngeal electromyography.

Tremors were not detected on laryngeal electromyography of the cricothyroid and thyroarytenoid muscles even in patients with clinical tremor. Laryngeal electromyography hypercontractility during voice rest was the typical result observed in Gender and age of subjects did not correlate with laryngeal electromyography results.

Patients with PD presented spontaneous intrinsic laryngeal muscle activity during voice rest, regardless of disease severity. This study was significant because it reported on the use of laryngeal electromyography in a large number of patients with PD and vocal complaints grouped according to PD severity. The patterns observed suggest that laryngeal electromyography is a valuable diagnostic tool for PD even at early phases of the disease. Diagnostics of the power oil-filled transformer equipment of thermal power plants.

Problems concerning improvement of the diagnostics efficiency of the electrical facilities and functioning of the generation and distribution systems through the examples of the power oil-filled transformers, as the responsible elements referring to the electrical part of thermal power plants TPP , were considered. Research activity is based on the fuzzy logic system allowing working both with statistical and expert information presented in the form of knowledge accumulated during operation of the power oil-filled transformer facilities.

The diagnostic algorithm for various types of transformers, with the use of the intellectual estimation model of its thermal state on the basis of the key diagnostic parameters and fuzzy inference hierarchy, was developed. Criteria for taking measures allowing preventing emergencies in the electric power systems were developed. The fuzzy hierarchical model for the state assessment of the power oil-filled transformers of kV, possessing high degree of credibility and setting quite strict requirements to the limits of variables of the equipment diagnostic parameters, was developed.

The most frequent defects of the transformer standard elements, related with the disturbance of the isolation properties and instrumentation operation, were revealed after model testing on the real object. Presented results may be used both for the express diagnostics of the transformers state without disconnection from the power line and for more detailed analysis of the defects causes on the basis of the advanced list of the diagnostic parameters; information on those parameters may be received only after complete or partial disconnection.

Oral case presentations provide an opportunity for trainees to communicate diagnostic reasoning at the bedside. However, few tools exist to enable faculty to provide effective feedback. We developed a tool to assess diagnostic reasoning and communication during oral case presentations. Thomson Parabola Spectrometer: a powerful tool to get on-line plasma information. Altana, C. The number of injuries caused by power tools is steadily increasing as more domestic woodwork is undertaken and more power tools are used recreationally.

The injuries caused by the different power tools as a consequence of accidents are an issue, because they can lead to substantial costs for patients and the national insurance system. The increase in hand surgery as a consequence of the use of power tools and its economic impact, and the characteristics of the hand injuries caused by power saws have been described. In recent years, the authors have noticed that, in addition to hand injuries, facial injuries caused by power tools commonly present to the emergency room.

This study aimed to review the data in relation to facial injuries caused by power saws that were gathered from patients who visited the trauma center at our hospital over the last 4 years, and to analyze the incidence and epidemiology of the facial injuries caused by power saws. The authors found that facial injuries caused by power tools have risen continually. Facial injuries caused by power tools are accidental, and they cause permanent facial disfigurements and functional disabilities.

Accidents are almost inevitable in particular workplaces; however, most facial injuries could be avoided by providing sufficient operator training and by tool operators wearing suitable protective devices. The evaluation of the epidemiology and patterns of facial injuries caused by power tools in this study should provide the information required to reduce the number of accidental injuries. An overview is provided of the analysis tools and techiques used in modeling the Space Station Freedom electrical power system, as well as future space vehicle power systems.

Development of asset management decision support tools become very intensive in order to reduce maintenance cost of power equipment due to the liberalization of power business. This article reviews some aspects of present status of asset management decision support tools development for power equipment based on the papers published in international conferences, domestic conventions, and several journals. Spectroscopy as a diagnostic tool for urban soil contaminants. Urbanization has become one of the major forces of change around the globe.

Land use transformation, especially urbanization has the most profound influences of human activities because it affects so many of the planet's physical and biological systems. Land use changes directly impact the ability of the earth to continue to provide ecological services to human society and the other occupants of the ecosystems. The urban process gradually degrades and transforms agricultural and natural ecosystems into built environments. The urban environment includes cities, suburbs, peri-urban areas and towns. Urban ecosystems are highly heterogeneous due to the variety of land covers and land purposes.

Thus, the choices on managing the extent and arranging the land cover patches e. As a result of ecological conditions and current management status the urban soils show substantial spatial heterogeneity. Whereas, adverse effects of pollutants on ecosystems have been demonstrated, one important need for environmental impact assessment have been defined as maintenance of long-term monitoring systems, which can enable to improve monitoring, modelling and assessment of various stressors in agriculture environment.

Diffuse reflectance spectroscopy and diffuse reflectance Fourier-transform infrared FTIR spectroscopy across visible-near- short- mid- and long- wave infrared 0. Relationships between spectral reflectance and soil properties, such as grain size distribution, moisture, iron oxides, carbonate content, and organic matter, have already been established in many studies Krishnan et al. The aims of this study are to develop diagnostic tool for heavy metals, polycyclic aromatic hydrocarbons, asbestos and other anthropogenic contaminants in urban soil using spectroscopy.

The power tool which will be used to replace the attitude control system in the SMM spacecraft was modified to operate from a self contained battery. The extravehicular mobility unit EMU battery was tested for the power tool application. The results are that the EMU battery is capable of operating the power tool within the pulse current range of 2.

Soft x-ray power diagnostics are essential for measuring spectrally resolved the total x-ray flux, radiation temperature, conversion efficiency and albedo that are important quantities for the energetics of indirect drive hohlraums. The Dante broadband spectrometer is a collection of absolute calibrated vacuum x-ray diodes, thin filters and x-ray mirrors used to measure the soft x-ray emission for photon energies above 50 eV.

The purpose of this study is to compare the accuracy of the GNRB arthrometer Genourob , Lachman test, and Telos device GmbH in acute anterior cruciate ligament ACL injuries and to evaluate the accuracy of each diagnostic tool according to the length of time from injury to examination. We divided the time from injury to examination into three periods of 10 days each and analyzed the diagnostic tools according to the time frame. An analysis of the area under the curve AUC of a receiver operating characteristic curve showed that all diagnostic tools were fairly informative.

In this article, I discuss some of the emerging applications and the future opportunities and challenges created by the use of mobile phones and their embedded components for the development of next-generation imaging, sensing, diagnostics and measurement tools. This rapidly evolving and continuing trend will help us transform how medicine, engineering and sciences are practiced and taught globally.